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In Short
Function Junction
Plugged In
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Food Pharmacy
Fall 1999
The virtual enzyme
Enzymes are the tools of life. They do almost everything in a cell. Virtually every one of life’s chemical reactions is driven by some enzyme. 

Enzymes are organic catalysts that work like a starter on a car. With a small input of energy from the starter, a car can run on its own energy all day.

Enzymes are not used up or changed when they “jumpstart” another molecule. They can perform the same task over and over.

Enzymes work very fast. They can carry out their task thousands of times per second.

Each enzyme has its own unique structural shape which allows it to bind to or “unlock” certain other molecules called substrates.

enzyme substrate interaction

When the correct “lock” and “key” come together, a chemical bond is formed. This event may help regulate a biochemical process or it may be one step in a sequence of programmed events.

Each enzyme’s unique structural shape is encoded in DNA.

When a mutation occurs in a gene that encodes an enzyme, the structural shape of the enzyme is often changed. Thus the enzyme may not be able to “unlock” its own substrates or otherwise function properly.

A dysfunctional enzyme may lead to a dysfunctional cell. 

 
Discover the Magic of Enzymes  Novozymes presents "Enzymes Illustrated,"  "Finding Enzymes," "The History of Enzymes" and more. 
Related links:
Enzymes and Enzyme Activity


Floating ball analogies for enzyme catalysis
 
Cool graphics that demonstrate how enzymes work.

Characteristics of enzymes 
Fourteen basic facts about enzymes.

What the Heck is an Enzyme?
A Kansas University professor explains biochemical catalysts using burning wood, personal 
relationships, and other humorous analogies. 

ExPASy biochemical pathway map of CPT

Simply Stated: Elevated Enzymes


For more about the differences between the CPT I and CPT II enzymes, visit Fundamental differences.  For more about the role of the CPT enzymes in mitochondrial metabolism, visit In graphic detail.
  

An important point to 
consider in CPT II deficiency is that the 
functional enzyme is 
actually made up of four subunits. If you have one normal copy of the gene and one mutant copy, or if you have a different mutation in each of your two CPT2 genes, these subunits may come together in many different combinations. Depending on how the defective and normal CPT2 subunits combine, you may get varying degrees of enzyme deficiency, resulting in variable symptoms.
     --G.D. Vladutiu, Ph.D.
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