 |
|
|
|
Probable cause |
|
|
|
| Changes in
hormones such as estrogen may trigger symptoms in patients with CPT II deficiency, suggests Stephen Zierz, M.D. “Numerous studies have established that total CPT activity and its kinetics are regulated by glucagon, insulin, and estrogen,” says Zierz, Professor of Neurology at the University of Halle-Wittenberg. Thus in patients with impaired regulation of CPT II, hormonal effects or changes have the potential to trigger symptoms. Zierz also notes that total CPT activity is significantly altered by fasting, diabetes, and hypothyroidism and is influenced by phospholipids.  Effect
of ovarian hormones on mitochondrial enzyme activity in the fat
oxidation pathway of skeletal muscle. Campbell
SE et al. Am J Physiol Endocrinol Metab
2001;281(4):E803-8Regulation
of liver carnitine palmitoyltransferase I gene expression by
hormones and fatty acids. Louet
JF et al. Biochem Soc Trans 2001 29(pt2):310-6Estradiol
may limit lipid oxidation via CPT I expression and hormonal
mechanisms. Gower
BA et al. Obes Res 2002 10(3):167-72 |
|
|||
| Reference:
Zierz S. "Carnitine Palmitoyltransferase Deficiency,"
Myology (McGraw-Hill, 1994) Related links: Effects of hypothyroidism, fasting and a ketotic diabetic state on liver carnitine palmitoyltransferases Estrogen may curb women's muscle pain NY Times report about a Canadian study that suggests women may be less prone to post-exercise muscle soreness than men. The story of hormonal changes McGill University links to information on estrogen and progesterone. Lack of sleep alters hormones and carbohydrate metabolism Doctor's Guide report on new research findings. 
To read more about triggers in CPT II deficiency, visit Triggers
survey results. To read about pregnancy in CPT II deficiency, visit Special
delivery.
|
|
|
|
|
|||
Muscle soreness is presumed to result from the body's
reactions to exercise-induced microtears in the muscle tissue.
Gender may play an important role in the susceptibility to
soreness. While research is still in the early stages, it is
possible that estrogen may be able to insert itself into cells
such as muscle membranes and stabilize them, which would
protect them from tearing. 
